Cytyc and Hologic Together
Breast Cancer Risk Assessment

Overview

The cytological analysis of the cells obtained by the FirstCyte® Breast Test provide clinicians with patient-specific, cell-based and minimally invasive assessment of a woman's breast cancer risk.

FirstCyte Breast Test Sample Preparation

Images of Cells Collected Using
the FirstCyte
Breast Test
•   Standardize collection procedures
•   Maintain cell architecture
•   Eliminate air-drying artifact
•   Reduce obscuring elements

 

Click on images below to view larger detail.
(All images 60x)

Benign
Benign

Mild Atypia
Mild Atypia

Mild Atypia
Mild Atypia

Marked Atypia
Marked Atypia

Marked Atypia
Marked Atypia

Malignant
Malignant

Collection


1. Collection
Collect sample directly into 30ml of CytoLyt® Solution in the CytoLyt tube.

Centrifugation

2. Concentrate by Centrifugation
(600g for 10 minutes)

Resuspend Cell Pellet

3. Pour Off Supernatant and Resuspend Cell Pellet
Resuspension can be done on a vortexor or may be achieved by syringing the pellet back and forth with a plastic pipette.

Evaluate

4.Add PreservCyt® from a PreservCyt Solution Vial.
Cap the tube tightly and mix by inversion to resuspend all the cells.

5. Add Specimen to PreservCyt Solution Vial
Allow to stand in PreservCyt Solution for 15 minutes.

Run ThinPrep Processor

6. Run on ThinPrep® Processor using Sequence 2 (FLU/FNA)
(Fix, stain, and evaluate)


Refer to the ThinPrep Processor Operator's Manual for detailed instrument and specimen preparation instructions.

Cytopathology Interpretation (Criteria)
  • Benign cells
  • Atypical cells
  • Malignant cells
  • Insufficient cellular material for diagnosis (ICMD)